Background Information

Babesia spp. are protozoal organisms that parasitize erythrocytes, causing anemia in the host. Many different species exist with varying host specificity. B. canis and B. gibsoni are two organisms commonly known to infect dogs. Both organisms have Ixodid tick vectors and are found throughout Asia, Africa, Europe, the Middle East, and North America, with B. canis being more prevalent. Cases of canine babesiosis may present with a wide variation of severity of clinical signs, ranging from a hyperacute, shock-associated, hemolytic crisis to an inapparent, subclinical infection. Dogs typically present with the acute form of babesiosis, which is characterized by general findings such as pyrexia, weakness, mucous membrane pallor, depression, lymphadenopathy, splenomegaly, and general malaise. Laboratory studies may document anemia, thrombocytopenia, hypoalbuminemia, and bilirubinuria. Initially, the anemia is normocytic, normochromic, and nonregenerative, but later develops into a macrocytic, hypochromic, regenerative anemia with reticulocytosis. The anemia is hypochromic because the reticulocytes have not yet formed their adult concentrations of hemoglobin.

LiliF™ BAB-C Kit is able to detect directly and specifically Babesia(B. canis, B. gibsoni) by CLP™ technology and Maxime ™ technology on the basis of a genetic database of target nucleic acid fragments. Therefore, this kit can diagnose very sensitive, fast and accurately. The kit contains a specific primer set for a highly conserved region based on current sequence alignments of Babesia(B. canis, B. gibsoni), allowing the DNA detection. It can determine the infecting all serotype and accurately and sensitivity detect multiple detection genes at one time using the conventional PCR method, and take only 2-3 hours for detection. Fast and sensitive detection of pathogen enables patients to get appropriate treatment and prevent the rapid spreading of disease by separating patients immediately.